Glenroy Dean Martin
Assistant Professor, Chemistry
- 1996 University of the West Indies, Jamaica, WI, B.S.
- 2003 University of the West Indies, Jamaica, WI, Ph.D.
- 2003-05 Scripps Institution of Oceanography, Postdoctoral Research Scholar
- 2005-06 Florida Atlantic University, Postdoctoral Research Associate
My research program at UT is focused on the isolation of bioactive natural products from terrestrial and marine sources. In particular, we are interested in natural products that possess antimicrobial, anti-inflammatory and anticancer activities. We incorporate a multidiscipline approach with students possessing skills in the areas of molecular biology, microbiology and chemistry. View website.
Marine Natural Products
Potent bioactive compounds are being isolated from marine microbes that are found in ocean sediment samples as well as those that are associated with marine invertebrates such as sponges, soft corals and tunicates. The pure microbial isolates are identified via molecular taxonomy and those which display good anti-inflammatory, antimicrobial and/or antitumor activities are grown in large scale liquid fermentations. The fermentations are extracted and concentrated to yield crude extracts. These extracts are purified on silica gel and HPLC to afford pure compounds. The characterization of these compounds (including their relative and absolute stereochemistry determination) is accomplished through one- and two- dimensional NMR as well as other spectroscopic and chemical means. The semi-synthesis and optimization of lead bioactive compounds are conducted by chemical and biochemical means where possible.
Biologically active analogs are being generated by the microbial bioconversion of their parent congeners via a variety of fungi. Presently, new analogs from the biotransformation of the chemopreventive agent curcumin and the anticancer compound formestane by the microorganisms Rhizopus oryzae and Beauveria bassiana respectively have been isolated.
Current work includes the isolation of bioactive toxins from saprophytic fungi that has shown to reduce the incidence of the citrus diseases Alternaria brown spot and melanose.
Reviews and Book Chapters
Martin, Glenroy D. A. Review: Biotransformation reactions by Rhizopus spp. Current Organic Chemistry, 14, 1-14 (2010).
Peer-Reviewed Publications without Undergraduate Co-authors
Martin, Glenroy D. A., Reynolds, William F., Reese, Paul B. Analysis of Salvia coccinea from Jamaica Populations. Natural Product Communications, 4, 789-790 (2009).
Martin, Glenroy D. A., Reese, Paul B., Durrant, Marcus C. A predictive cytochrome P450 monooxygenase functional model for generic hydroxylation by Rhizopus oryzae ATCC 11145. Journal of Theoretical and Computational Chemistry, 7, 421-433 (2008).
Martin, Glenroy D. A., Tan, Lik T., Jensen, Paul R., Dimayuga, Rosalba Encarnacion, Fairchild, Craig R., Raventos-Suarez, Carmen, Â Fenical, William. Marmycins A and B, Cytotoxic Pentacyclic C-Glycosides from a Marine Sediment-Derived Actinomycete Related to the Genus Streptomyces. Journal of Natural Products, 70,1406-1409 (2007).
Martin, Glenroy D. A., Reynolds, William F., Reese, Paul B. Rearrangement of the stemodane skeleton to novel analogues: chemistry and microbial transformation. Phytochemistry, 66, 901-909 (2005).
Martin, Glenroy D. A., Reynolds, William F., Reese, Paul B. Investigation of the importance of the C-2 oxygen function in the transformation of stemodin analogues by Rhizopus oryzae ATCC 11145. Phytochemistry, 65, 701-710 (2004).
Martin, Glenroy D. A., Reynolds, William F., Reese, Paul B. Investigation of the importance of the C-2 and C-13 oxygen functions in the transformation of stemodin analogues by Rhizopus oryzae ATCC 11145. Phytochemistry, 65, 2211-2217 (2004
Peer-Reviewed Publications with Undergraduate Co-authors: [Undergraduates underlined]
Martin, Glenroy D. A., Williams, Jesica R., McPhee, Jennifer L., Mercer, Bettie L. Bioconversion of curcumin by Beauveria bassiana and Aspergillus niger. Journal of Natural Products, In preparation.
Shaw, Scott K., Marti, Anne M., Martin, Glenroy D. A. Synthesis and bioconversion of formestane and its analogs. Journal of Natural Products, In preparation.
Christensen, Anna M., Martin, Glenroy D. A. Phylogenetic diversity of bacteria cultured from marine sediments. Applied and Environmental Microbiology, In preparation.